Nemours Children's Clinic employs 445 pediatric subspecialty physicians at sites in Delaware and Florida. Nemours is dedicated to providing treatment and curative services to acutely and chronically ill children. Nemours mission is to provide leadership, institutions, and services to restore and improve the health of children through care and programs not readily available, with one high standard of quality and distinction regardless of the recipient's financial status. This is in addition to the many ongoing research programs that are also conducted at Nemours. There are a number of research projects underway in areas such as spinal trauma, gait analysis and bone density.

Nemours owns and operates the Alfred I. duPont Hospital for Children in Wilmington, Delaware, as well as four major Children's specialty centers in Wilmington, Jacksonville, Orlando, and Pensacola. The Hospital features the nation's largest academic pediatric orthopedic practice, as well as a specialized cancer program for children.