Baptist Medical Center Downtown, a 599-bed tertiary hospital that is the flagship of Baptist Health in Jacksonville, Florida, is centrally located on the south bank of the St. Johns River. Serving a region that is expanding both geographically and economically, Baptist Downtown provides a comprehensive range of services, including: cardiology and cardiovascular care through Baptist Heart Hospital; oncology (including gynecologic oncology); women's health services, including obstetrics, gynecology and a Women's Health Center; and ophthalmology.

Other major services include:

• emergency care (including Life Flight's air ambulance)
• the adult emergency center
• the children's emergency center
• hyperbaric medicine
• critical care
• bloodless medicine and surgery
• pulmonary services
• a sleep disorders center
• pastoral care
• radiology
• rehabilitation
• psychiatry/psychology

Additionally, Baptist Downtown has the following regional referral centers: Jacksonville Orthopedic Institute, located in the Reid Medical Building; and Baptist Cancer Institute, located in the Edna Williams Cancer Center. The downtown campus is home to Wolfson Children's Hospital, the area's only children's hospital; and adjacent to the downtown campus is Nemours Children's Clinic a premier pediatric research clinic.

Baptist Health incorporates the tertiary hospital in downtown Jacksonville, a 122-bed full service medical center in Jacksonville Beach, a 54-bed acute care hospital in Amelia Island and a brand new full service hospital in South Jacksonville.